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Datum[@Name='Schema Config DCR']Royal Bank of Canadahttps://www.rbcroyalbank.com/personal.htmlhttps://www.rbcroyalbank.com/personal.htmlInsights1200630enCA
Datum[@Name='Source DCR']2020-05-26New business models emergeWill genetics usher in a new era of healthcare? Is the entire health ecosystem ready for reinvention? Can digital healthcare in life sciences exceed patient expectations?Expanding Ecosystems3/assets/rbccm/images/gib/healthcare/article_3_thumbnail_sm.jpg/assets/rbccm/images/gib/healthcare/article_3_thumbnail.jpg<h3>Shifting Paradigms</h3>
<p>As the convergence of healthcare and technology has accelerated, new business models are rapidly emerging. </p>
<p>In the traditional biopharma model, the customer would be a physician, R&D tools would be chemical or biological, the end product a pill or vial, and the competitors pharma and biotech players.</p>
<p>The digital revolution in healthcare is shifting this long-established paradigm. Today, biopharma companies’ customer groups have grown to include patients of all ages, providers and payers—all equipped with smartphones and apps that generate a vast amount of digital information to empower their decision-making. R&D has added genetic information and digital capability to its toolset. The end product has broadened beyond the pill to include health outcomes enabled by digital devices and therapeutics. And the competitive set has seen the addition of technology players, including consumer-focused apps and online services, as well as digital health and digital therapeutics firms.</p>
<p class="photo-frame text-center"><img style="width: 100%;" src="/assets/rbccm/images/gib/healthcare/Healthcare-Article-3-Graph-1.png" alt="" /></p>
<h3>A Changing Ecosystem</h3>
<p>Indeed, digital and AI applications are radically changing key areas of the biopharma ecosystem and how patients manage their healthcare.</p>
<p>In pre-clinical research, technology is enabling everything from a deeper mining of literature, to predictive modeling and gene-function annotation. Digital apps are simulating molecular dynamics and pushing the limits of cellular imaging.</p>
<p>In clinical trials, digital transformation is helping to automate testing procedures, build global patient databases and collect real-world data.</p>
<p>In diagnostics, tech powers digital pathology, home-based body diagnosis, and computational analysis of tissue arrays. Just like your car leaves the factory with hundreds of sensors that can trigger the check engine light, humans will have wearable and/or implantable sensors to alert them when something is not functioning properly. Another burgeoning area is immune cell monitoring and digital analysis through just a finger prick.</p>
<p>At the point of patient care, digital applications are already delivering virtual consultations, remote monitoring, VR-based cognitive therapy and digital Rx. Demand for telehealth services and health-based social platforms is also increasing and especially vital in a world facing new challenges such as the COVID-19 pandemic.</p>
<p><img src="/assets/rbccm/images/gib/healthcare/healthcare-article-3-graph-2.png" alt="AI and Digital applications are changing key areas of the Healthcare Ecosystem" /></p>
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<h3>Digital Transformation</h3>
<p>The digital revolution presents both threats and opportunities to incumbent biopharma companies. Tech is powering efficiencies in all stages of the current ecosystem and is also enabling healthcare providers to expand their capabilities from treatment to prevention.</p>
<div class="quotebox">
<p>“Tech is powering efficiencies in all stages of the current ecosystem and is also enabling healthcare providers to expand their capabilities.”</p>
<p class="attribution" style="color: #0070a3;">– Greg Wiederrecht, Ph.D.</p>
<div class="quote-share">
<p style="display: inline-block;"><span style="margin-right: 15px;">Share </span><a class="blue-circle-outline-sm" href="https://www.linkedin.com/shareArticle?mini=true&url=https%3A//www.rbccm.com/en/gib/healthcare/episode/new_healthcare_business_models_emerge&title=New%20healthcare%20business%20models%20emerge&source=www.rbccm.com" target="_blank" rel="noopener" aria-label="Connect by LinkedIn"><em class="fa fa-linkedin" style="color: #0051a5; margin-left: 3px;"> </em></a> <a class="blue-circle-outline-sm" href="https://twitter.com/home?status=New%20business%20models%20emerge%20https%3A//www.rbccm.com/en/gib/healthcare/episode/new_healthcare_business_models_emerge" target="_blank" rel="noopener" aria-label="Connect by X"><em class="fa fa-twitter" style="color: #0051a5; margin-left: 3px;"> </em></a> <a class="blue-circle-outline-sm" href="mailto:?subject=New%20business%20models%20emerge&body=I%20found%20this%20insights%20piece%20from%20RBC%20Capital%20Markets%20informative%20and%20thought%20it%20might%20be%20of%20interest%20to%20you%3A%0D%0Dhttps%3A//www.rbccm.com/en/gib/healthcare/episode/new_healthcare_business_models_emerge&title=New business models emerge" aria-label="Connect by Email"><em class="fa fa-envelope" style="color: #0051a5; margin-left: 3px;"> </em></a></p>
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<p> </p>
<p>The increased digitization of human experiences gives access to a wealth of information and knowledge that could help intervene before disease has a chance to strike. A prime example of this is collating data from an Apple Watch to screen for irregular heart rhythms and detect undiagnosed atrial fibrillation. At the other end of the spectrum, digital transformation allows a completely new class of therapies such as digital therapeutics to support specific disorders.</p>
<p>McKinsey and Company’s international survey shows that more than 75% of patients expect to use digital healthcare services in the future.<sup>1</sup> Patients are seeking technology that delivers a level of care they can rely on and trust. Ultimately, the aim of the digital revolution is to develop healthier societies and lower the cost of care.</p>
<p style="word-wrap: break-word;"><sup>1 Source: McKinsey and Company, Healthcare’s Digital Future, July 2014. https://www.mckinsey.com/~/media/McKinsey/Industries/Healthcare%20Systems%20and%20Services/Our%20Insights/Healthcares%20digital%20future/Healthcares%20digital%20future.ashx</sup></p><ul>
<li>Customer groups, R&D and competitors are all rapidly expanding</li>
<li>Tech is reinventing every facet of the biopharma ecosystem</li>
<li>Innovations in patient care is driving adoption of digital services</li>
</ul>text2 min1 minHealthcare Models, Digital Healthcare, Digital Healthcare Apps, Digital Health Diagnostics, Expanding R&D, Healthcare & Tech Convergence, Healthcare Services, Clinical Trials, Remote Patient Monitoring, Digital Therapeutics, Biopharma ecosystem, Cost of CareN/templatedata/rbccm/episode/data/healthcare/amazon_cvs_and_google_healthcare_reimagined/templatedata/rbccm/episode/data/healthcare/big_tech_vs_big_pharma/templatedata/rbccm/episode/data/healthcare/the_healthcare_data_explosionGreg Wiederrecht, Ph.D./assets/rbccm/images/gib/healthcare/greg-wiederrecht.jpgManaging Director, Healthcare Investment Bankinggreg.wiederrecht@rbccm.comhttps://www.linkedin.com/in/gregwiederrecht/Sasson Darwish/assets/rbccm/images/gib/healthcare/sasson-darwish.jpgManaging Director, AI, Analytics and IoT & Israel Country Coverage, Global Technology Investment Bankingsasson.darwish@rbccm.com https://www.linkedin.com/in/sassdarwish/Andrew Callaway/assets/rbccm/images/gib/healthcare/andrew-callaway.jpgManaging Director, Global Head of Healthcare Investment Bankingandrew.callaway@rbccm.comhttps://www.linkedin.com/in/andrew-cal-callaway
DEBUG: DCR
DCRRoyal Bank of Canadahttps://www.rbcroyalbank.com/personal.htmlhttps://www.rbcroyalbank.com/personal.htmlInsights1200630enCA
DCR2020-05-26New business models emergeWill genetics usher in a new era of healthcare? Is the entire health ecosystem ready for reinvention? Can digital healthcare in life sciences exceed patient expectations?Expanding Ecosystems3/assets/rbccm/images/gib/healthcare/article_3_thumbnail_sm.jpg/assets/rbccm/images/gib/healthcare/article_3_thumbnail.jpg<h3>Shifting Paradigms</h3>
<p>As the convergence of healthcare and technology has accelerated, new business models are rapidly emerging. </p>
<p>In the traditional biopharma model, the customer would be a physician, R&D tools would be chemical or biological, the end product a pill or vial, and the competitors pharma and biotech players.</p>
<p>The digital revolution in healthcare is shifting this long-established paradigm. Today, biopharma companies’ customer groups have grown to include patients of all ages, providers and payers—all equipped with smartphones and apps that generate a vast amount of digital information to empower their decision-making. R&D has added genetic information and digital capability to its toolset. The end product has broadened beyond the pill to include health outcomes enabled by digital devices and therapeutics. And the competitive set has seen the addition of technology players, including consumer-focused apps and online services, as well as digital health and digital therapeutics firms.</p>
<p class="photo-frame text-center"><img style="width: 100%;" src="/assets/rbccm/images/gib/healthcare/Healthcare-Article-3-Graph-1.png" alt="" /></p>
<h3>A Changing Ecosystem</h3>
<p>Indeed, digital and AI applications are radically changing key areas of the biopharma ecosystem and how patients manage their healthcare.</p>
<p>In pre-clinical research, technology is enabling everything from a deeper mining of literature, to predictive modeling and gene-function annotation. Digital apps are simulating molecular dynamics and pushing the limits of cellular imaging.</p>
<p>In clinical trials, digital transformation is helping to automate testing procedures, build global patient databases and collect real-world data.</p>
<p>In diagnostics, tech powers digital pathology, home-based body diagnosis, and computational analysis of tissue arrays. Just like your car leaves the factory with hundreds of sensors that can trigger the check engine light, humans will have wearable and/or implantable sensors to alert them when something is not functioning properly. Another burgeoning area is immune cell monitoring and digital analysis through just a finger prick.</p>
<p>At the point of patient care, digital applications are already delivering virtual consultations, remote monitoring, VR-based cognitive therapy and digital Rx. Demand for telehealth services and health-based social platforms is also increasing and especially vital in a world facing new challenges such as the COVID-19 pandemic.</p>
<p><img src="/assets/rbccm/images/gib/healthcare/healthcare-article-3-graph-2.png" alt="AI and Digital applications are changing key areas of the Healthcare Ecosystem" /></p>
<div id="similar-to-this" style="border-top: 2px #E6E6E7 dotted; border-bottom: 2px #E6E6E7 dotted; margin: 35px 0; padding: 25px;">
<h4 style="font-size: 18px; letter-spacing: 0.5px; border-bottom: 3px #FEDF01 solid; padding: 0 0 8px 0; margin-bottom: 15px;">Similar to this</h4>
</div>
<h3>Digital Transformation</h3>
<p>The digital revolution presents both threats and opportunities to incumbent biopharma companies. Tech is powering efficiencies in all stages of the current ecosystem and is also enabling healthcare providers to expand their capabilities from treatment to prevention.</p>
<div class="quotebox">
<p>“Tech is powering efficiencies in all stages of the current ecosystem and is also enabling healthcare providers to expand their capabilities.”</p>
<p class="attribution" style="color: #0070a3;">– Greg Wiederrecht, Ph.D.</p>
<div class="quote-share">
<p style="display: inline-block;"><span style="margin-right: 15px;">Share </span><a class="blue-circle-outline-sm" href="https://www.linkedin.com/shareArticle?mini=true&url=https%3A//www.rbccm.com/en/gib/healthcare/episode/new_healthcare_business_models_emerge&title=New%20healthcare%20business%20models%20emerge&source=www.rbccm.com" target="_blank" rel="noopener" aria-label="Connect by LinkedIn"><em class="fa fa-linkedin" style="color: #0051a5; margin-left: 3px;"> </em></a> <a class="blue-circle-outline-sm" href="https://twitter.com/home?status=New%20business%20models%20emerge%20https%3A//www.rbccm.com/en/gib/healthcare/episode/new_healthcare_business_models_emerge" target="_blank" rel="noopener" aria-label="Connect by X"><em class="fa fa-twitter" style="color: #0051a5; margin-left: 3px;"> </em></a> <a class="blue-circle-outline-sm" href="mailto:?subject=New%20business%20models%20emerge&body=I%20found%20this%20insights%20piece%20from%20RBC%20Capital%20Markets%20informative%20and%20thought%20it%20might%20be%20of%20interest%20to%20you%3A%0D%0Dhttps%3A//www.rbccm.com/en/gib/healthcare/episode/new_healthcare_business_models_emerge&title=New business models emerge" aria-label="Connect by Email"><em class="fa fa-envelope" style="color: #0051a5; margin-left: 3px;"> </em></a></p>
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<p> </p>
<p>The increased digitization of human experiences gives access to a wealth of information and knowledge that could help intervene before disease has a chance to strike. A prime example of this is collating data from an Apple Watch to screen for irregular heart rhythms and detect undiagnosed atrial fibrillation. At the other end of the spectrum, digital transformation allows a completely new class of therapies such as digital therapeutics to support specific disorders.</p>
<p>McKinsey and Company’s international survey shows that more than 75% of patients expect to use digital healthcare services in the future.<sup>1</sup> Patients are seeking technology that delivers a level of care they can rely on and trust. Ultimately, the aim of the digital revolution is to develop healthier societies and lower the cost of care.</p>
<p style="word-wrap: break-word;"><sup>1 Source: McKinsey and Company, Healthcare’s Digital Future, July 2014. https://www.mckinsey.com/~/media/McKinsey/Industries/Healthcare%20Systems%20and%20Services/Our%20Insights/Healthcares%20digital%20future/Healthcares%20digital%20future.ashx</sup></p><ul>
<li>Customer groups, R&D and competitors are all rapidly expanding</li>
<li>Tech is reinventing every facet of the biopharma ecosystem</li>
<li>Innovations in patient care is driving adoption of digital services</li>
</ul>text2 min1 minHealthcare Models, Digital Healthcare, Digital Healthcare Apps, Digital Health Diagnostics, Expanding R&D, Healthcare & Tech Convergence, Healthcare Services, Clinical Trials, Remote Patient Monitoring, Digital Therapeutics, Biopharma ecosystem, Cost of CareN/templatedata/rbccm/episode/data/healthcare/amazon_cvs_and_google_healthcare_reimagined/templatedata/rbccm/episode/data/healthcare/big_tech_vs_big_pharma/templatedata/rbccm/episode/data/healthcare/the_healthcare_data_explosionGreg Wiederrecht, Ph.D./assets/rbccm/images/gib/healthcare/greg-wiederrecht.jpgManaging Director, Healthcare Investment Bankinggreg.wiederrecht@rbccm.comhttps://www.linkedin.com/in/gregwiederrecht/Sasson Darwish/assets/rbccm/images/gib/healthcare/sasson-darwish.jpgManaging Director, AI, Analytics and IoT & Israel Country Coverage, Global Technology Investment Bankingsasson.darwish@rbccm.com https://www.linkedin.com/in/sassdarwish/Andrew Callaway/assets/rbccm/images/gib/healthcare/andrew-callaway.jpgManaging Director, Global Head of Healthcare Investment Bankingandrew.callaway@rbccm.comhttps://www.linkedin.com/in/andrew-cal-callaway
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12024-10-16Insights from a Wall Street Legend: An Interview with Larry GrafsteinWith over $1 trillion in transactions under his belt, Larry Graftein, Deputy Chairman, Global Investment Banking, RBC Capital Markets, shares career insights and deal strategies. strategicInsights<li><a href="/en/">Home</a></li><li><a href="/en/insights.page">Insights </a></li><li><a href="/en/gib/ma-inflection-points.page">Strategic Alternatives</a></li>Home | Insights | Strategic Alternatives/assets/rbccm/images/insights/2024/202410-insights-from-a-wall-street-legend-an-exclusive-interview-th.jpg/assets/rbccm/images/insights/2024/202410-insights-from-a-wall-street-legend-an-exclusive-interview-banner.jpghttps://player.captivate.fm/episode/4ca6897c-0dfe-40a2-bb36-1de24958c369/https://www.rbccm.com/en/story/story.page?dcr=templatedata/article/story/data/2024/10/insights-from-a-wall-street-legend-an-exclusive-interviewstrategic<h2>A career built on unconventional beginnings</h2>
<p>Larry Grafstein’s journey into investment banking is far from typical. With a background steeped in politics and law, Larry’s path to finance was unintended but serendipitous. His academic journey saw him accumulate three degrees before venturing into the financial sector. From advising clients on nearly $1 trillion in transactions to holding top positions at Lazard, Rothschild, and UBS, Larry’s career is a testament to his versatility and dedication.</p>
<h2>Learning from experience</h2>
<p>Larry emphasized that good judgment is born from experience, which often includes a fair share of mistakes. His key takeaway for aspiring finance professionals: do not let anxiety cloud your early career. Focus on building relationships and working on interesting projects. “Invest in learning and let things fall into place,” he advised.</p>
<h2>The power of networking</h2>
<p>In an era where maintaining relationships is simpler than ever, thanks to technology, Larry encourages young professionals to leverage these tools. Reflecting on his relationships, such as with Boris Johnson and Emmanuel Macron, he highlighted the importance of nurturing connections as today’s peers could be tomorrow’s industry titans.</p>
<h2>Balancing act: career and beyond</h2>
<p>Larry’s advocacy for a balanced life resonated throughout the interview. He stressed the importance of prioritizing personal pursuits and family, alongside career ambitions. This balance, he suggests, is crucial for long-term success and personal fulfillment. Larry’s involvement in numerous charities and boards demonstrates his commitment to giving back, which adds a layer of satisfaction to his professional achievements.</p>
<h2>Winning in investment banking</h2>
<p>When it comes to winning multi-billion-dollar deals, Larry’s approach is strategic and empathetic. Understanding clients’ needs and presenting unique solutions are at the heart of his methodology. He shared vivid experiences, such as resolving one of the most hostile transactions in history involving Market Basket Supermarkets, illustrating that finance, at its core, is about people and relationships.</p>
<h2>Looking ahead: opportunities and learnings</h2>
<p>Larry is cautiously optimistic about the future of finance, encouraging professionals to learn from past cycles and be prepared for volatility. He underscored the importance of understanding both the quantitative and psychological aspects of crises.</p>
<div class="well"><a title="Link to Altrum Episode" href="https://www.altrum.com/resources/dealtoys/insights-from-a-wall-street-legend-an-exclusive-interview-with-larry-grafstein/" target="_blank" rel="noopener">This episode was originally recorded with The Investment Banking Leaders Podcast on September 23, 2024.</a></div><ul>
<li>Originally recorded with The Investment Banking Leaders Podcast, Larry Grafstein sits down for a conversation with Peter Nieberg.</li>
<li>Larry has over 30 years of experience in the investment banking industry, and has overseen $1 trillion in completed transactions.</li>
<li>Larry shares his unconventional journey from law and politics to investment banking, offering valuable insights on building relationships, winning major deals, and achieving a work-life balance.</li>
</ul>/en/insights/transcripts/insights-from-a-wall-street-legend.pageaudio1 min52 minenglobal1/templatedata/rbccm/authors/data/larry-grafsteinlarry-grafsteinLarry Grafstein Deputy Chairman, Global Investment BankingN/assets/rbccm/images/authors/Larry%20Grafstein.jpghttps://www.linkedin.com/in/larry-grafstein-4597a219b/<p><strong>Larry Grafstein</strong> has been Deputy Chairman of the Global Investment Banking at RBC Capital Markets since September of 2018. In his 30 years on Wall Street, he has advised clients on nearly $1 trillion of completed transactions. His experience spans all industries and geographies and includes some of the largest and most complex M&A, restructuring, equity and privatization deals. </p>
<p>His clients over the years have included AerCap, AT&T, BAT, Charter Communications, Creative Artists Agency, Fiat Chrysler Automobiles, Hutchison Whampoa, Intel, Jabil, Juniper, Leucadia, Level 3, Microsoft, Mosaic, Sprint, Time Warner, TPG, Visteon and Vodafone. Recently he advised CSX on its response to activist investor Mantle Ridge, IBM on its acquisition of Truven, and Molson Coors on its acquisition of its Miller Coors JV. He advised on the restructurings of WorldCom and Nortel, two of the largest done to date. </p>
<p>He has worked on behalf of the Governments of Canada and Ontario regarding their investments in Chrysler and General Motors after the financial crisis and advised on the landmark privatizations of Telefonos de Mexico and Telstra of Australia. He recently represented Statewide Mobility Partners, a consortium of investment funds, on the divestiture of Indiana Toll Roads, one of the largest infrastructure sales in US history. In 2014 he helped settle the strike and consumer boycott at Market Basket Supermarkets in New England through the sale by certain members of the Demoulas family of their ownership stake and resolution of their 20-year control dispute.</p>
<p>Mr. Grafstein is a graduate of Harvard University (B.A.), Oxford University (M.Phil, Balliol College, Rhodes Scholar), and the University of Toronto (J.D.). He is co-chair of his Harvard class and has served on the board of a number of public companies and philanthropic institutions, including the US board of Upper Canada College and the board of trustees of Horace Mann School in New York.</p>Peter NiebergAltrumN/assets/rbccm/images/authors/peter-nieberg.jpgBy Larry Grafstein <br> Hosted By: Peter Nieberg, AltrumBy Larry Grafstein <br> Hosted By: Peter Nieberg, Altrum1/templatedata/article/story/data/2024/10/bond-markets-accelerate-but-volatil/templatedata/article/story/data/2024/09/healthy-debt-markets-are-driving-deal-flow/templatedata/article/story/data/2024/09/why-us-banks-are-set-for-strong-performanceinsights, strategic alternativesWith over $1 trillion in transactions under his belt, Larry Graftein, Deputy Chairman, Global Investment Banking, RBC Capital Markets, shares career insights and deal strategies. RBC Capital Markets, Larry Grafstein, Investment Banking, Investment Banking Leaders PodcastRBC Capital Markets, Larry Grafstein, Investment Banking, Investment Banking Leaders Podcast, Strategic Alternatives